OBJECTIVES: Recently, the widespread surge in smartphone addiction (SA) has raised major global health concerns and prompted researchers to scrutinize the inverse relationship between physical activity (PA) and the risk of SA. This systematic literature review aims to synthesize the empirical research on the relationship between PA and SA among university students representing the most affected age group. METHODS: Adopting the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, we explored five databases: PubMed, Social Sciences Research Network (SSRN), Oxford Research Archive, Journal Storage (JSTOR), and Google Scholar. We used the Mixed Methods Appraisal Tools (MMAT) for quality assessment. RESULTS: Thirty-one studies met the inclusion criteria. Twenty-eight of them were cross-sectional, and three were experimental. The 31 studies emerged from 12 countries, most stemming (45.16%) from China. Their findings suggest an inverse relationship between PA and SA in the examined population. However, the direct relationship may be weak based on correlational studies, while intervention research yields noteworthy effects. Still, other factors like resilience may mediate the studied relationship. Methodological concerns render the results of correlational studies tentative. CONCLUSIONS: Regular PA could be a promising preventive measure for SA. Future work should use objective PA indices in longitudinal research designs while assessing the type and duration of smartphone applications used via device meters. In correlational studies, interviews should follow up on the high SA risk or too much device use. In conclusion, moderate evidence indicates that PA can reduce SA among university students.

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