BACKGROUND AND METHODS: the aim of the study is to evaluate the clinical efficacy of three treatment approaches: standard conservative treatment (SCT), SCT combined with tendon and nerve gliding exercises, and tendon and nerve gliding exercises alone. An interventional study was conducted in the Department of Orthopaedics, Gandhi medical college (GMC), Hamidia Hospital, Bhopal (MP) with 34 patients to assess the clinical efficacy between 3 randomized groups. RESULTS: A total of 34 patients diagnosed with intermediate-stage CTS participated in the study. By the end of the treatment, all groups showed significant improvements in symptoms and functionality. However, patients in Groups 1 (n = 12) and 2 (n = 11) experienced significantly greater recovery compared to those in Group 3 (n = 11; p < 0.05). Patient satisfaction was assessed an average of 11 months post-treatment, revealing that the percentages of asymptomatic patients were significantly higher in Groups 1 and 2 compared to Group 3 (p = 0.03 and p = 0.008, respectively). CONCLUSIONS: This study demonstrated that all three conservative treatment modalities- Steroid Combined Therapy (SCT), SCT combined with tendon and nerve gliding exercises, and tendon and nerve gliding exercises alone-are effective in managing Carpal Tunnel Syndrome (CTS). However, SCT combined with tendon and nerve gliding exercises was found to be the most effective in reducing symptoms, improving functional outcomes, and achieving higher patient satisfaction.

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