INTRODUCTION: The combined use of methadone and exercise training holds promise for promoting health. This study investigates the impact of resistance and aerobic training in conjunction with methadone consumption on lipid profiles and C-reactive protein (CRP) levels in addicted men. MATERIALS AND METHODS: Ninety addicted men (mean age 36.82 +/- 4.32 years) undergoing prison treatment were randomly assigned to six groups (n = 15 each): control, narcotics anonymous (NA), aerobic training plus methadone, aerobic training plus methadone reduction, resistance training plus methadone, resistance training plus methadone reduction. The 12-week exercise program, conducted thrice weekly, included aerobic training (4 to 8 sets, 3 minutes each, at 80 to 90% maximum heart rate on the ergometer bike) and resistance training (12 repetitions, 3 sets, at 70 to 85% of one repetition maximum). Blood samples collected pre- and post-intervention measured CRP and blood lipids using specialized kits. Data were analyzed with SPSS software, employing multiple analysis of variance (MANOVA) and Tukey's post hoc test (p < 0.05). RESULTS: High-density lipoprotein (HDL) levels significantly increased in trained groups compared to the control (p < 0.001). Moreover, trained groups exhibited significant decreases in low-density lipoprotein (LDL), triglycerides, total cholesterol, and CRP compared to the control group (p < 0.05). Importantly, aerobic training was more effective than resistance training in improving the studied variables. CONCLUSION: Exercise training, particularly aerobic training with methadone ingestion, yields positive effects, including reduced CRP levels and improved lipid profiles in addicted men. Exercise training with methadone reduction may be considered for empowering individuals with addiction issues.

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