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| Randomized controlled effect of treadmill walking exercise on liver enzymes, psychological burden, and erectile dysfunction in men with hepatitis C |
| Ismail AMA, El Gressy NSSA, Hegazy MD, Elfahl AMA-H, Ahmed OSM |
| Przeglad Gastroenterologiczny 2024;19(3):263-270 |
| clinical trial |
| 5/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
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INTRODUCTION: Exercise is a simple, safe, and affordable solution that can be easily taught to men with chronic illnesses to improve their psychological burden and sexual health. AIMS: Since the role of exercise in ameliorating the psychological burden associated with erectile dysfunction (ED) in hepatitis C (HC) men was not explored, this research aimed to explore this role. MATERIALS AND METHODS: This HC study was a randomized-controlled exercise-rehabilitation trial. Recruitment of HC men with ED was conducted from El-Sahel Teaching Hospital, Cairo, Egypt. Men (n = 46) were randomly assigned to a 12-week walking-exercise group (WEG, n = 23 HC men with ED received a 1-hour treadmill walking 3 times weekly) or a control group (n = 23 HC men with ED, who did not change their daily physical activity during the research period). Besides Beck's Depression Inventory (BDI), Arabic Version of the Five-Item Version International Index of Erectile Function (IIEF-5), Profile of Mood States Questionnaire (POMSQ), and Ten-Statement Rosenberg self-esteem scale (TSRSE), HC participants' liver enzymes, alanine transaminase (ALT), and aspartate transaminase (AST) were assessed. RESULTS: Significant improvements of POMSQ, BDI, AST, IIEF-5, ALT, and TSRSE within the WEG only were seen. No significant changes occurred in the control group's parameters. CONCLUSIONS: Exercise (walking) is a good modality to improve liver enzymes, ED, and ED-associated psychological burden (depression, low self-esteem, and mood disturbances) in HC men with ED.
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