BACKGROUND: This study aimed to observe the clinical effects of He Tiao Du Ren An Shen Acupuncture (HTDRAS Acupuncture) for treating restless leg syndrome (RLS). METHODS: We randomly divided 66 RLS patients into 2 groups: the observation group received He Tiao Du Ren An Shen Acupuncture and the control group received conventional acupuncture. All participants were treated once a day, 6 days a week, with 1 day off, for a total of 1 month. Clinical effectiveness of the 2 groups was compared, neurotransmitter levels, the International Restless Leg Syndrome Scale and the Hamilton Anxiety Scale were assessed in both groups. RESULTS: The curative effect in the observation group was better than that in the control group (p < 0.05). After treatment, the expression of 5-hydroxytryptamine in the observation group was higher than in the control group (p < 0.05). The International Restless Leg Syndrome Scale and Hamilton Anxiety Scale scores in observation group were lower than those in control group (p < 0.05). CONCLUSION: He Tiao Du Ren An Shen Acupuncture for RLS is significantly effective and safe. It can effectively improve the levels of 5-hydroxytryptamine in RLS patients, alleviate clinical symptoms and reduce anxiety. This treatment has a high clinical application value and is worthy of clinical promotion.

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