INTRODUCTION: One of the most common causes of elbow pain is tennis elbow disorders. Sufferers of this disorder complain of pain, decreased grip strength, and reduced functional activities that may have a significant impact on daily activities and lifestyle. Therefore, the aim of the present study was to determine the impact of instrument-assisted soft tissue mobilization (IASTM) on the quality of life of patients with tennis elbow disorders. MATERIALS AND METHODS: 44 non-athletes with tennis elbow disorder were selected purposefully and available and randomly divided into two experimental groups (13 males and 9 females) and control (16 males and 6 females). Participants in the control group received a single injection of corticosteroids, 10 sessions of physiotherapy, and daily use of a tennis elbow splint for one month, while the patients in the intervention group, in additionto receiving the interventions of the control group, received IASTM for two sessions each week for 4 weeks for 10 minutes. The patients' quality of life was measured using the SF-36 questionnaire before and after the intervention. The statistical test included one-way ANOVA, which was analyzed by SPSS V.26 at a level of significance less than 0.05. RESULTS: After the intervention, the average score of the quality of life subscales wasn't significantly different between the two groups (p < 0.05), but the total quality of life score of the intervention group was significantly different from the control group (p < 0.001). CONCLUSION: The use of IASTM along with common interventions for the treatment of tennis elbow can be effective in improving the quality of life.

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