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The force awakening in HbA1c control: a systematic review and meta-analysis on the efficacy of high-intensity and endurance exercise in patients with type 2 diabetes mellitus
Munoz Rossi FA, Cabarcas Rua JA, Quinapanta Castro NI, Cedillo Orellana SI, Baez M, Coronel J, Zambrano Delgado DM, Mejia Nates V, Leon PA, Reche Martinez AJ
Cureus 2024 Nov;16(11):e73401
systematic review

The increase in the global prevalence of type 2 diabetes mellitus (DM2), driven mainly by obesity and physical inactivity, has increased interest in various nonpharmacological therapies. This systematic review aims to establish the effectiveness of high-intensity interval training (HIIT) and resistance exercise (RE) compared with continuous aerobic exercise in improving control in patients with DM2. We conducted a comprehensive search for clinical trials using databases such as MEDLINE (PubMed) and Web of Science. The search was performed using a controlled vocabulary (MeSH) together with Boolean operators, and the results were limited to English and Spanish. Secondary outcomes were improvements in VO2max and decreases in low-density lipoprotein (LDL). This study aims to explain evidence-based recommendations for primary care physicians on exercise therapies to improve glycemic management as well as cardiovascular health in people with DM2.

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