Sanogenetic effects of physical factors that have an activating effect on the adaptation-compensatory mechanisms of the body are known. On the other hand, their comparative effect on the pathogenetic links of the disease has been proven. It is advisable to use them in comorbid pathology of the digestive system to increase the effectiveness of rehabilitation measures. OBJECTIVE: To study the effectiveness of the developed complex of exercise therapy (ET) in outpatient medical rehabilitation programmes for patients with colorectal cancer (CRC) in combination with chronic pancreatitis (CP). MATERIAL AND METHODS: There have been observed 84 patients with CRC after surgical treatment in combination with CP. The patients were divided into 2 groups by simple randomization: the comparison group (CG; 40 people) underwent a diet therapy, standard exercise therapy, psychocorrection, pharmacotherapy (Pinaveria bromide), and internal intake of mineral waters of low mineralization; in the main group (MG; 44 people) the patients had rehabilitation therapy according to the original method (RU 143601 from 20.05.2024). The effectiveness of the outpatient rehabilitation was assessed by indicators of the quality of life (Gastroenterological Quality of Life Questionnaire GSRS: and European Quality of Life Questionnaire EQ-5D), bioelectrical activity of rectus abdominis muscles. RESULTS: After implementing the rehabilitation course, it was stated on repeated electromyography that the total amplitude of bioelectrical activity of the rectus abdominis muscle with the patients of the MG has improved relative to the initial value by 1.9 (p < 0.01) with between-group differences (p < 0.05). A positive dynamics of GSRS quality of life indicators showed that a more significant (p < 0.05) decrease in the intensity of clinical manifestations was observed in the MG. According to the EQ-5D questionnaire, the quality of life indicators according to the scales Mobility, Pain and discomfort and Anxiety and depression also improved more significantly in the MG with between-group differences (p < 0.05). CONCLUSION: The inclusion of the original exercise therapy technique in the outpatient medical rehabilitation programmes for CRC after surgical treatment in combination with CP helps to restore the impaired functions of the digestive organs and improve their quality of life.

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