BACKGROUND: The Multiwave Locked System (MLS) has been shown to reduce inflammation and enhance biostimulation. OBJECTIVES: The aim was to investigate the effect of using MLS laser in reducing pain severity in patients with chronic back pain. METHODS: This randomized double-blind study was conducted on 30 patients (15 in each group) with chronic low back pain (LBP) who were referred to Imam Khomeini Hospital and diagnosed by a physical medicine specialist based on diagnostic criteria. The intervention group was treated with MLS multiple wave laser, performed 12 times, with patients receiving laser treatment twice a week. The control group was treated with exercise therapy. Pain intensity was evaluated using the Visual Analog Scale (VAS) before treatment and 6 weeks after treatment. Pain was analyzed before and after the intervention, both within and between groups. RESULTS: Of the 30 evaluated patients, the mean and standard deviation of age (p = 0.392) and gender (p = 0.666) were not statistically significant between the two groups. The VAS value before treatment in the intervention and control groups was 7.66 +/- 1.11 and 7.73 +/- 1.16, respectively (p = 0.794). After treatment, the VAS values in the MLS and control groups were 5.60 +/- 1.35 and 7.73 +/- 1.16, respectively. Statistical evaluation showed a statistically significant difference between the two groups (p = 0.001), and the total change in VAS values was significant (p = 0.001). CONCLUSIONS: Multiwave Locked System laser can reduce the pain severity of chronic LBP, with the reduction rate in the intervention group being significantly higher than in the exercise group.

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