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| Exercise improves myocardial deformation but not cardiac structure in preterm-born adults: a randomized clinical trial [with consumer summary] |
| Lapidaire W, Mohamed A, Williamson W, Huckstep OJ, Alsharqi M, Tan CMJ, Burden S, Dockerill C, Woodward W, McCourt A, Burchert H, Kenworthy Y, Biasiolli L, Dawes H, Foster C, Leeson P, Lewandowski AJ |
| JACC 2025 May;4(5):101721 |
| clinical trial |
| This trial has not yet been rated. |
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BACKGROUND: People born preterm (< 37 weeks' gestation) have a potentially adverse cardiac phenotype that progresses with blood pressure elevation. OBJECTIVES: The authors investigated whether preterm-born and term-born adults exhibit similar cardiac structural and functional remodeling following a 16-week aerobic exercise intervention. METHODS: We conducted a randomized controlled trial in 203 adults (aged 18 to 35 years) with elevated blood pressure or stage 1 hypertension. Participants were randomized 1:1 to a 16-week aerobic exercise intervention or to a control group. In a prespecified cardiovascular magnetic resonance imaging (CMR) substudy, CMR was performed at 3.0-Tesla to assess left and right ventricular (LV and RV) structure and function before and after intervention. RESULTS: A total of 100 participants completed CMR scans at baseline and after the 16-week intervention, with n = 47 in the exercise intervention group (n = 26 term-born; n = 21 preterm-born) and n = 53 controls (n = 32 term-born; n = 21 preterm-born). In term-born participants, LV mass to end-diastolic volume ratio decreased (-3.43; 95% CI -6.29 to -0.56; interaction p = 0.027) and RV stroke volume index increased (5.53 mL/m 2; 95% CI 2.60 to 8.47; interaction p = 0.076) for those in the exercise intervention group versus controls. No significant effects were observed for cardiac structural indices in preterm-born participants. In preterm-born participants, LV basal- and mid-ventricular circumferential strain increased (-1.33; 95% CI -2.07 to -0.60; interaction p = 0.057 and -1.54; 95% CI -2.46 to -0.63; interaction p = 0.046, respectively) and RV global longitudinal strain increased (1.99%; 95% CI -3.12 to -0.87; interaction p = 0.053) in the exercise intervention group versus controls. No significant effects were observed for myocardial deformation parameters in term-born participants. CONCLUSIONS: Aerobic exercise training induces improved myocardial function but not cardiac structure in preterm-born adults.
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