BACKGROUND: Mild cognitive impairment (MCI) represents an early stage of cognitive loss that significantly increases the risk of dementia. The aim of this study was to comprehensively synthesize the current evidence on the effect of combined physical and cognitive therapies in older adults with MCI. METHODS: A systematic review with meta-analysis was conducted by searching for specific keywords in the PubMed, Scopus, Cinhal, and Web of Science databases. This meta-analysis included a total of 2256 participants distributed across 21 studies that evaluated the benefits of combining physical exercise with cognitive stimulation. RESULTS: This review revealed that these types of therapies present a significant improvement in memory, attention, and executive functions. Participants showed notable improvements in these cognitive areas, highlighting the synergistic effects of physical exercise and cognitive stimulation, which exceeded the benefits of each therapy separately. These results contribute to the understanding of how these combined therapies can improve cognitive health in this population, offering robust evidence supporting their application in clinical practice. CONCLUSIONS: This meta-analysis shows that combined physical exercise and cognitive stimulation interventions may be an effective strategy for improving cognitive health in older adults with MCI. The findings of this study offer a valuable contribution to the field, highlighting the potential of these combined therapies to prevent cognitive decline and improve the quality of life of this population. The results may be of interest to health professionals and guide future research and clinical applications.

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