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Acute effects of a single bout structured resistance and combined exercise on blood glucose profile during exercise in patients with type 2 diabetes and healthy adults: a randomized crossover study
Huang Y-M, Liu Z, Fu J, Shan P-F, Wang J, Wen X
Diabetes Research and Clinical Practice 2025 Mar;221:112031
clinical trial
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AIMS: The effects of postprandial resistance and combined exercise on blood glucose profiles, particularly in patients with type 2 diabetes, remain unclear. Comprehending these responses may aid in diabetes management. METHODS: Three trials were conducted: trial A examined aerobic, resistance, and combined exercise; trials B and C focused on three intensities of resistance and combined exercise. Participants including patients with type 2 diabetes and healthy adults completed a randomized crossover experiment with two arrangements of three interventions and continuous glucose monitoring. Blood glucose iAUC and slope were analyzed via repeated measures two-way ANOVA. RESULTS: A total of 21 patients with type 2 diabetes (47.81 +/- 11.88 years) and 26 healthy adults (31.77 +/- 6.66 years) were assigned. In trials A-C, the main effect of subject group on iAUC/min was significant (p < 0.001, p = 0.003, and p < 0.001). The exercise in trial A (p = 0.006) and subject group in trial C (p = 0.005) significantly impacted the blood glucose slope. CONCLUSIONS: Resistance and combined exercise reduce postprandial hyperglycemia in type 2 diabetes patients. Monitoring glucose before exercise may help prevent extreme events.
With permission from Excerpta Medica Inc.

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