BACKGROUND: This research aims to investigate the performance of 8 weeks of aerobic exercise and vitamin D supplementation on nitric oxide (NO) and endothelin 1 (ET-1) indicators in patients with high blood pressure and vitamin D deficiency. MATERIALS AND METHODS: In this quasi-experimental research, 40 qualified men and women were randomly divided into four groups (supplement group, placebo plus exercise group, supplement plus exercise group, and control group). The training program of the experimental groups included 8 weeks of aerobic exercise running on a treadmill (3 sessions per week). Two groups (exercise plus supplement and supplement group) received vitamin D supplement daily in the amount of 2000 international units in a double-blind manner, and the exercise plus placebo group received a placebo capsule containing maltodextrin daily. Blood sampling was done to evaluate biochemical variables 48 hours before and after the intervention in a fasting state. RESULTS: The research results show that after 8 weeks of aerobic training with vitamin D supplementation, there was no significant effect on body mass index, NO, triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), vitamin D, and weight (p < 0.05), but the effects were significant on ET-1 level and systolic blood pressure which changed in the supplement, supplement plus exercise, and exercise plus placebo groups compared to the control group (p < 0.05). Also, the vitamin D increase showed a significant change (p < 0.05). CONCLUSIONS: Based on the results of the present study, taking vitamin D supplements for 8 weeks along with aerobic activity reduces ET-1, increases NO, and improves blood pressure in hypertensive people with vitamin D deficiencies.

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