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The effect of exercise on quality of life among patients and survivors of breast cancer: a systematic review and meta-analysis
Gupta B, Gupta K, Narula K, Sharma P, Mittal A
Asian Pacific Journal of Cancer Prevention 2025 Mar 1;26(3):715-723
systematic review

INTRODUCTION: The impact of physical activity on the quality of life in breast cancer patients and survivors is examined in this study by a comprehensive meta-analysis of randomized control trials. MATERIALS AND PROCEDURES: We searched databases like PubMed, Scopus, Embase, and Google Scholar for research publications published between 2005 and 2024, using the PRISMA guidelines. R software was utilised to perform the meta-analysis, and Cochrane's ROB 2.0 tool was employed to assess the quality of the studies. We utilised the I2 statistics to evaluate heterogeneity. A funnel plot and Egger's regression test were used to determine publication bias. RESULTS: The pooled effect of training on overall health-related quality of life (HRQOL) in survivors and patients of breast cancer was estimated to have been 0.70 (CI 95% 0.41 to 0.99) using a random effects model. HRQOL was calculated using Functional Assessment of Cancer Therapy-Breast (FACT-B) outcomes in breast cancer survivors and patients with cancer following giving them physical training and fitness intervention. The downward trend in the meta-regression study suggests that younger people benefited more from exercise in terms of quality of life than older patients. Participants in Asia (1.72 (CI 95% -0.60 to 4.05)), America (0.52 (CI 95% 0.30 to 0.74)), and Australia (0.43 (CI 95% 0.24 to 0.61)) had a stronger effect of the treatment compared to patients in Europe (0.51 (CI 95% -0.12 to 1.15)), according to sub-group analysis. CONCLUSION: Physical activity enhances breast cancer patients' and survivors' health-related quality of life.

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