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Effects of an additional multimodal intervention (MultiMove) during inpatient rehabilitation on clinical and functional outcomes in patients with chronic low back pain -- a pilot trial
Nguyen T, Behrens M, Broscheid K-C, Bielitzki R, Rohkohl K, Rudolph I, Meiler K, Franke J, Schega L
BMC Musculoskeletal Disorders 2025 Apr 16;26(372):Epub
clinical trial
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BACKGROUND: As a leading cause of disability, chronic low back pain (CLBP) is a musculoskeletal condition often associated with impaired physical and cognitive functions. Due to its multi-factorial facets, the application of multimodal interventions is recommended. MultiMove is a multimodal intervention designed for CLBP patients, which combines motor-cognitive and dancing exercises. This study aimed to assess the effects of an additional MultiMove intervention to a standard inpatient rehabilitation on clinical and functional outcomes in CLBP patients. METHODS: For this prospective, two-arm, controlled pilot trial, 27 CLBP patients (17 females, 10 males) undergoing a 3-week inpatient rehabilitation, in a rehabilitation clinic in Germany, were recruited. The intervention group (IG, n = 15, 61.6 +/- 1.8 years) received a daily MultiMove session in addition to the standard rehabilitation, while the control group (CG, n = 12, 63.8 +/- 2.2 years) followed the standard rehabilitation. Physical (Timed Up and Go (TUG) (primary outcome), Five-Repetition Sit-to-Stand (FRSTS), and Six-Minute Walk Test (6MWT), trunk range of motion, single and dual task walking)), clinical (acute/chronic pain intensity, Oswestry Disability Index, EQ-5D-5 L), cognitive (Stroop Color Word Test, Trail Making Test), and psychosocial outcomes (Tampa Scale of Kinesiophobia, Beck Depression Inventory-II, Coping Strategies Questionnaire) were assessed during the first (pre-test) and last day (post-test) of the inpatient rehabilitation. RESULTS: The statistical analyses revealed improvements in trunk range of motion (sagittal plane: p = 0.018, d 1.00; transversal plane: p = 0.006, d 1.18) and 6MWT performance (p = 0.003, d 1.30) in the IG compared to the CG. Moreover, lower dual task costs for a gait variability measure (p = 0.034, d 0.97) as well as reduced chronic pain intensity (p = 0.004, d 1.33), kinesiophobia (p = 0.035, d 1.15), and depression (p = 0.034, d = 1.08) were found in favour of the IG. CONCLUSION: Data indicate that the multimodal intervention MultiMove improved clinical and functional outcomes in CLBP patients during inpatient rehabilitation. Therefore, conducting a randomized controlled trial with a large sample size is recommended to verify and extent these results. TRIAL REGISTRATION: MultiMove project (German Clinical Trial Register, ID: DRKS00021696 / 10.07.2020, https://drks.de/drks_web/navigate.do?navigationId=trial.HTML26TRIAL_ID=DRKS00021696) and was carried out in the rehabilitation clinic Bad Salzelmen (Schonebeck, Germany).

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