BACKGROUND: Patellofemoral pain syndrome (PFPS) is a knee disorder characterised by pain behind or surrounding the patella that predominantly affects adolescents. OBJECTIVES: This study aimed to evaluate the impact of laser acupuncture (LA) on pain, range of motion (ROM), and function in patients diagnosed with PFPS. MATERIALS AND METHODS: Sixty participants, predominantly young women aged 18 to 25years, were randomly distributed into two equal groups: Group A (LA group), which received laser acupuncture (LA) applied to six knee acupoints at 4J for 80s/point, in conjunction with an exercise programme; and Group B (Sham LA group), which received LA with the device deactivated, along with an exercise programme including stretching and strengthening exercises. Both groups underwent the intervention twice a week for 4weeks. Pain, knee range of motion (ROM), and function were evaluated at baseline and post-treatment using the visual analogue scale (VAS), goniometer, and Kujala score, respectively. RESULTS: No significant differences were observed in the VAS, ROM, and Kujala scores for knee flexion and extension between the two groups before treatment (p > 0.05). However, Group A showed a significant reduction in VAS scores (p < 0.001) and a significant improvement in the Kujala score and ROM for knee flexion and extension (p < 0.001) compared with Group B. CONCLUSIONS: Four-week LA intervention combined with an exercise programme demonstrated greater improvements in pain, knee ROM, and functional ability than the exercise programme alone. However, the results cannot be generalised, as the sample was mostly composed of young women aged 18 to 25years. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT06610981.

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