BACKGROUND: Hamstring tightness is a common musculoskeletal issue that can lead to reduced strength, flexibility, and impaired quality of life, particularly among females. Muscle Energy Technique (MET) is frequently used to enhance flexibility and muscle performance; however, its impact on quality of life remains unclear. The aim is to evaluate the role of Muscle Energy Technique in improving hamstring muscle strength and quality of life among females with hamstring tightness. MATERIALS AND METHODS: A total of 90 female college students aged 25 to 50 years with clinically diagnosed hamstring tightness were randomly assigned to two groups. Group A (n = 45) received MET, while Group B (n = 45) received conventional physiotherapy consisting of moist heat application and passive stretching. Hamstring flexibility was assessed using the Active Knee Extension Test (AKET), muscle strength through standard strength testing, and quality of life using validated questionnaires. The intervention lasted four weeks, and pre-and post-test comparisons were analyzed statistically. RESULTS: Group A demonstrated a significant improvement in muscle strength post-intervention (p = 0.012) compared to Group B. However, changes in quality of life within and between groups were minimal and not statistically significant (p = 0.978). Flexibility (AKET scores) improved significantly in both groups, with Group B showing greater gains (p < 0.001). CONCLUSION: Muscle Energy Technique significantly improved hamstring strength; however, neither MET nor conventional interventions produced meaningful short-term improvements in quality of life. This suggests that isolated muscle-focused interventions may not be sufficient to enhance overall well-being, highlighting the need for long-term, comprehensive rehabilitation approaches.

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