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Responders COPD patients to two different home-based rehabilitation programs: a blind, randomized, and controlled clinical trial [with consumer summary]
da Silva MMC, Ferreira Arcuri J, Viana DR, Marrara KT, Zorrer Franco FJB, de Souza NM, Bueno LG, de Oliveira BSV, Galhardo Rizzatti FP, Gibertoni LCF, Di Lorenzo VAP
Disability and Rehabilitation 2025;47(15):3897-3904
clinical trial
This trial has not yet been rated.

PURPOSE: To verify the number of patients with COPD responders to two different home-based rehabilitation programs. METHODS: This was a blinded, randomized, and controlled clinical trial. The six-minute step test (6MST), one-minute sit-stand test (1-MSTST), six-minute walk test (6MWT), COPD Assessment Test (CAT), modified Medical Research Council (mMRC), monitoring of physical activity in daily life, and isometric quadriceps muscle strength were assessed pre- and post-intervention. A total of 50 patients were randomized into two groups: hybrid rehabilitation (HR), consisting of supervised physical exercise once a week associated with exercises at home, and home-based rehabilitation (HBR), which consisted of a single meeting for guidance related to the physical exercises prescribed. RESULTS: Significant differences (p < 0.05) were observed in the following parameters post-intervention and between groups: 6MST (HR 67.1 +/- 25.7 to 93.5 +/- 37.2; HBR 69.6 +/- 19.5 to 82.3 +/- 25.2 steps), 6MWT (HR 367.7 +/- 84 to 433.2 +/- 88.8; HBR 396.2 +/- 97.2 to 418.3 +/- 83.8 m), CAT (HR 19.5 +/- 6.8 to 13.0 +/- 7.8; HBR 17.0 +/- 7.6 to 15.0 +/- 10 points), and mMRC (HR 2 (2 to 3) to 1 (1 to 2); HBR 2 (2 to 3) to 2 (1 to 3) points). However, the response rate was 80% in the HR and 50% in the HBR. CONCLUSION: Both pulmonary rehabilitation programs improved physical capacity, alleviated dyspnea, and reduced the impact of the disease on health status; however, the number of responders was higher in the HR.

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