PURPOSE: Systematic review with meta-analysis to evaluate the efficacy of resistance training (RT) in improving pain intensity, quality of life, and disability in people with nonspecific chronic low back pain (NSCLBP). METHOD: Searches were conducted in April 2025 using MEDLINE, Scopus, Web of Science, and the Cochrane Library. Randomized controlled trials (RCTs) that compared RT interventions with any treatment and assessed pain intensity, quality of life, or disability in adults with NSCLBP were included. A pairwise random-effects meta-analysis was performed by subgroup according to the comparison treatment. Risk of bias was assessed with the Cochrane Risk of Bias 2.0 tool (RoB 2), and certainty of evidence was evaluated using the GRADE approach. RESULTS: Ten RCTs (n = 434) showed significant improvements in pain intensity (SMD -1.15; 95% CI -1.67 to -0.62, p < 0.0001) and disability (SMD -2.76; 95% CI -3.90 to -1.62, p < 0.00001) favoring RT. No statistical or clinical significance was observed in the quality of life. Only pain intensity reached clinical significance. The certainty of the evidence was rated as moderate for all variables. CONCLUSIONS: RT programs effectively reduce pain intensity and disability in patients with NSCLBP. Moderate certainty of evidence suggests that RT can be recommended for NSCLBP. Further research is required to confirm these findings. PROSPERO REGISTRATION NO.: CRD42024505897.

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