BACKGROUND/OBJECTIVES: Dyspnoea and functional decline are common among cancer patients with associated respiratory conditions. This study aimed to evaluate the effectiveness of an Effort Re-education Programme (ERP) in improving functionality and quality of life in hospitalised oncology patients compared to Conventional Clinical Practice (CCP). METHODS: A stratified, randomised, prospective clinical trial was conducted involving 65 patients with cancer and associated respiratory conditions. Participants were assigned to either a control group (CCP) or an experimental group (ERP plus CCP). Functionality (Barthel Index), health-related quality of life (EORTC QLQ-C30), overall performance (Karnofsky Scale), and instrumental activities of daily living (Lawton and Brody Scale) were assessed at baseline and one month post-discharge. RESULTS: The ERP group showed significantly greater improvements in all outcome measures: Barthel Index (mean change: +18.33 versus +6.19), EORTC QLQ-C30 (+16.4 versus +6.6), Karnofsky (+18.75 versus +5.6), and Lawton-Brody (+2.78 versus +0.78), all with p < 0.001 and moderate-to-large effect sizes (Cohen's d 0.72 to 1.19). No readmissions were reported in the ERP group, versus 37.5% in the control group. CONCLUSIONS: The ERP significantly improves basic and instrumental functionality, autonomy, and health-related quality of life in oncology patients with respiratory conditions. These findings support the integration of Functional Re-education Programmes into routine clinical practice as a complement to standard care.

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