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Effects of neurodevelopmental therapy on motor performance of infants with Down's syndrome
Harris SR
Developmental Medicine and Child Neurology 1981 Aug;23(5):477-483
clinical trial
6/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: No; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

A group of 20 infants with Down's syndrome, aged between two months and 21 months, was tested initially on the Bayley Scales of Infant Development and the Peabody Developmental Motor Scales. Four treatment objectives were developed for each individual infant, and they were then randomly assigned to an experimental or control group. The experimental group were given an individual neurodevelopmental therapy program three times a week in their own homes for a period of nine weeks. When the infants were post-tested on the Bayley and Peabody Scales, no significant difference was found between the two groups. However, there was a statistically significant difference in favour of the experimental group in attainment of individual treatment objectives.

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