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Comparison of different treatments of venous leg ulcers: a controlled study using stereophotogrammetry
Eriksson G, Eklund AE, Liden S, Zetterquist S
Current Therapeutic Research, Clinical and Experimental 1984;35(4):678-684
clinical trial
1/10 [Eligibility criteria: No; Random allocation: Yes; Concealed allocation: No; Baseline comparability: No; Blind subjects: No; Blind therapists: No; Blind assessors: No; Adequate follow-up: No; Intention-to-treat analysis: No; Between-group comparisons: No; Point estimates and variability: No. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed*

In order to evaluate different methods of topical treatment of venous leg ulcers, randomized controlled studies were performed in 53 patients. Stereophotogrammetry was used as an objective method of measurement of the healing process. No difference was found in the rate of healing between saline or dextranomer bead treatment in the initial two-week period. During the following eight weeks, three different treatments were compared, namely x-ray sterilized freeze-dried porcine skin, a dressing with an aluminium foil surface and a double layer bandage consisting of an inner stocking impregnated with zinc oxide paste and an outer elastic bandage. After four weeks the double layer bandage was found superior to aluminium foil and from six weeks onwards better results were obtained also with the porcine skin. The treatment had to be interrupted because of poor effect in six patients in the aluminium foil group. The treatment with the double layer bandage had to be abandoned in no case. Accordingly, based upon the overall results of the second period, the double layer bandage is to be recommended.

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