Detailed Search Results
| Author/Association: | Rolving N, Brocki BC, Bloch-Nielsen JR, Larsen TB, Jensen FL, Mikkelsen HR, Ravn P, Frost L |
| Title: | Effect of a physiotherapist-guided home-based exercise intervention on physical capacity and patient-reported outcomes among patients with acute pulmonary embolism: a randomized clinical trial [with consumer summary] |
| Source: | JAMA Network Open 2020 Feb;3(2):e200064 |
| Method: | clinical trial |
| Method Score: | 8/10 [Eligibility criteria: Yes; Random allocation: Yes; Concealed allocation: Yes; Baseline comparability: Yes; Blind subjects: No; Blind therapists: No; Blind assessors: Yes; Adequate follow-up: Yes; Intention-to-treat analysis: Yes; Between-group comparisons: Yes; Point estimates and variability: Yes. Note: Eligibility criteria item does not contribute to total score] *This score has been confirmed* |
| Consumer Summary: | KEY POINTS: QUESTION: Can a rehabilitation intervention consisting of physiotherapist-guided home-based exercise intervention and nurse consultations improve physical capacity and quality of life among patients with acute pulmonary embolism more than nurse consultations alone? FINDINGS: In this randomized clinical trial of 140 participants, improvements in physical capacity and quality of life were achieved with no differences between the intervention and control groups. No adverse events were reported. MEANING: Adding an exercise intervention to nurse consultations did not increase physical capacity or quality of life, but the study findings were limited by a highly selected group of patients with a low burden of comorbidity, exhibiting ceiling effects on the physical capacity measure. |
| Abstract: | IMPORTANCE: Survivors of acute pulmonary embolism (PE) experience long-term negative physical and mental consequences, but the effects of rehabilitation on outcomes among these patients have not been investigated. OBJECTIVE: To investigate the effect of a rehabilitation intervention, comprising an 8-week home-based exercise program and nurse consultations, on physical capacity and patient-reported outcomes among patients with acute PE. DESIGN, SETTING, AND PARTICIPANTS: This multicenter randomized clinical superiority trial was conducted at 4 regional hospitals and 1 university hospital in Denmark. The 140 consecutively included participants had been diagnosed with an acute PE between April 2016 and February 2018 and had 6 months of follow-up. An intention-to-treat analysis was conducted. INTERVENTION: Patients in the control group received a brief nurse consultation, while patients in the exercise group participated in an 8-week home-based exercise program in addition to receiving nurse consultations. MAIN OUTCOMES AND MEASURES: The primary outcome was the Incremental Shuttle Walk Test, and secondary outcomes were the Pulmonary Embolism Quality of Life and the EuroQol -- 5 Dimensions -- 3 Levels questionnaires, self-reported number of sick-leave days, and self-reported use of psychotropic drugs. RESULTS: A total of 140 patients (90 (64.3%) men) were included, with a mean (SD) age of 61 (11) years. Of 70 participants (50.0%) randomized to each group, 69 participants (49.3%) received the intervention and 68 (48.6%) received the control intervention. Both groups achieved improvements in all outcomes (eg, mean (SD) improvement on Incremental Shuttle Walk Test control group 78 (127) m, intervention group 104 (106) m; median (interquartile range) improvement on Pulmonary Embolism Quality of Life control group -17 (-22 to -11) points, intervention group -20 (-24 to -15) points). Between-group differences were nonsignificant. The mean differences between the intervention group and the control group were 25 m (95% CI -20 to 70 m; p = 0.27) on the Incremental Shuttle Walk Test, 3.0 points (95% CI -3.7 to 9.9 points; p = 0.39) on the Pulmonary Embolism Quality of Life questionnaire, and 0.017 point (95% CI -0.032 to 0.065 point; p = 0.50) on the EuroQol -- 5 Dimensions -- 3 Levels questionnaire. Of the 27 patients in the intervention group on sick leave at baseline, 24 (88.9%) reported fit-for-duty at the 6-month follow-up, and of 18 patients in the control group on sick leave, 17 (94.4%) reported fit-for-duty at the 6-month follow up. The between-group risk difference was not significant (5.5 points; p = 0.49). CONCLUSIONS AND RELEVANCE: An 8-week rehabilitation intervention with exercise added to nurse consultations did not show significantly better outcomes than nurse consultations alone. However, because of a ceiling effect on the primary outcome of physical capacity and an inclusion of patients with a low comorbidity burden and low PE disease severity, definitive conclusions could not be drawn. Initiating an exercise intervention shortly after pulmonary embolism was safe and without adverse events. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT02684721. Full text (sometimes free) may be available at these link(s):  help |
